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HairScience N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles.

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2015

N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles.

Arch Dermatol Res 2015; 307 (9): 841-847.

Spermidine (Spd), the prototypic polyamine,has been shown to be essential for hair follicle (HF)growth. However, Spd can be readily converted into other polyamines, and is physiologically unstable.Therefore, to assess its individual functions on HFs, we used the metabolically stable Spd analog N1-methyl spermidine (N1-MeSpd).

N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles.

Ramot Y et al.